Category: What is Cancer
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Hallmarks of Cancer – From2000 to 2022
The Hallmarks of Cancer In 2000, Hanahan and Weinberg enumerated 6 cancer hallmarks: 1) self-sufficiency in growth signals, 2) insensitivity to growth-inhibitory (antigrowth) signals, 3) evasion of programmed cell death (apoptosis), 4) limitless replicative potential, 5) sustained angiogenesis, and 6) tissue invasion and metastasis. Hallmarks of Cancer: The Next Generation In 2011, Two emerging hallmarks […]
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What is PAM50 for breast cancer?
PAM50 is a list of 50 genes that classify breast cancers into one of five intrinsic subtypes from formalin-fixed, paraffin-embedded tissues by real time polymerase chain reaction (RT-PCR). Initially developed on microarray data, PAM50 is being successfully used in digital multiplexed gene expression platforms such as NanoString nCounter®, which is the basis for the Prosigna® […]